解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We studied the prevalence of mitochondrial gene mutations in subjects with insulin-dependent diabetes mellitus (IDDM) in a Chinese population living in Taiwan. Eighty-four subjects with insulin-dependent diabetes mellitus and 105 unrelated normal controls were recruited in the present study. Both an A-to-G mutation at...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199604000-00006
更新日期:1996-04-01 00:00:00
abstract::Pancreatic necrosis as a consequence of acute pancreatitis usually implies a poor prognosis. Infection is the most common complication affecting mortality and appears to be increasing. While bacterial infections, particularly with coliforms, account for the majority of cases of infected necrosis, fungal infections are...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:
更新日期:1996-04-01 00:00:00
abstract::Our objective was to analyze conservative management in a large series of acute necrotizing pancreatitis (ANP) patients in a specialized center for pancreatic disease in the Internal Medicine and Emergency Department of a 1,500-bed hospital. One hundred ninety-nine patients with ANP were considered (mean age, 55.4 +/-...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199603000-00006
更新日期:1996-03-01 00:00:00
abstract::To investigate the role of insulin in the potentiation effect of secretin and cholecystokinin (CCK) on pancreatic exocrine secretion, the pancreas was isolated from rats and perfused with modified Krebs-Henseleit solution containing glucose at three concentrations. Intraarterial glucose at concentrations of 2.5, 10, a...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199601000-00007
更新日期:1996-01-01 00:00:00
abstract::To investigate the heterogeneity of hematogenous metastases of pancreatic ductal carcinoma, we investigated carcinomatous spread in 130 autopsy cases. Hepatic metastases occurred most frequently, in 81 cases (62%), which may be explained by the fact that all veins draining the pancreas flow into the portal system. We ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199511000-00005
更新日期:1995-11-01 00:00:00
abstract::Pancreatic duct bicarbonate secretion is mediated primarily by secretin-induced elevation of intracellular cyclic AMP, although little is known of the effects of other physiological regulators on pancreatic duct cyclic AMP metabolism. We investigated the effects of secretin and several other potential agonists on cycl...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199510000-00008
更新日期:1995-10-01 00:00:00
abstract::Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199508000-00005
更新日期:1995-08-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) is synthesized in islet B cells and stored in the secretory granules. We examined whether IAPP and insulin are released in parallel in humans. Arginine hydrochloride (5 g) was injected intravenously at three glucose levels in 11 healthy 58-year-old female subjects. In the fasting state...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199508000-00015
更新日期:1995-08-01 00:00:00
abstract::It has been suggested that the severity of an attack of acute pancreatitis is related to the presence of intraglandular trypsinogen activation and that disease severity is also reflected by the degree of the acute-phase protein response. In this study we examine the relationships among amylase release, the degree of t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199505000-00005
更新日期:1995-05-01 00:00:00
abstract::Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcin...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199505000-00004
更新日期:1995-05-01 00:00:00
abstract::This study compared diet, type of alcoholism, and smoking in three groups of alcoholic men, with chronic pancreatitis (n = 56), with histological cirrhosis (n = 50), and without pancreatitis or cirrhosis (controls; n = 50) by a multidimensional analysis. Only patients in whom the first symptom of pancreatitis or cirrh...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00003
更新日期:1995-04-01 00:00:00
abstract::Recent studies have demonstrated that cholecystokinin (CCK) receptor antagonists not only reduce the severity of pancreatitis but also inhibit pancreatic regeneration after pancreatitis. This study was undertaken, therefore, to examine the effects of the CCK receptor antagonist loxiglumide on the exocrine pancreas whe...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199504000-00011
更新日期:1995-04-01 00:00:00
abstract::Nicotine is a possible risk factor for chronic pancreatitis and pancreatic cancer. To study the loci where nicotine might exert its effect, we examined interactions between nicotine and rat pancreatic acini. When pancreatic acini were incubated with [3H]nicotine, [3H]nicotine levels in pancreatic acini were increased ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199503000-00008
更新日期:1995-03-01 00:00:00
abstract::Free radicals have been implicated in beta-cell destruction. pancreatic antioxidant enzymatic defenses provide significant endogenous protection from these highly cytotoxic effector molecules. In our colony of BB rats, the reliability of peripheral blood lymphocyte count (PBLC) as a predictor of diabetes onset was ass...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199501000-00007
更新日期:1995-01-01 00:00:00
abstract::Over 80% of adenocarcinomas of the pancreas originate from duct cells, which are the major source of mucins in the pancreas. Pathological conditions produce changes in the composition and structure of the oligosaccharides of colonic and pancreatic mucins, and it has been suggested that mucins may have a role in the de...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199411000-00002
更新日期:1994-11-01 00:00:00
abstract::The nuclear DNA content was assessed by image cytometry on cytologic specimens obtained with fine-needle aspiration biopsy in 96 patients with pancreatic duct carcinoma. Twenty-two of these patients had pancreaticoduodenal resection. According to DNA analysis there were 27 (28%) diploid, 17 (18%) tetraploid, and 52 (5...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199411000-00016
更新日期:1994-11-01 00:00:00
abstract::Pancreatic acinar cells within the islets of Langerhans in human pancreas were investigated both histopathologically and electron microscopically. Acinar cells inside the islets of Langerhans were observed in all 50 adult cases investigated. Between such acinar cells and endocrine tissues, no reticular fiber was obser...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199409000-00004
更新日期:1994-09-01 00:00:00
abstract::Adenosine-5'-O-(2-thiodiphosphate) (ADP beta S), a P2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. In the present work the effects of ADP beta S on insulin somatostatin, and glucagon secretions were investigated in dogs. In vivo, in anesthetized fasted dogs, i.v...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Protein phosphatases have recently been recognized to represent an important, independently regulated portion of cellular signaling cascades. Although reversible phosphorylation of multiple pancreatic proteins has been described, suggesting a role for these enzymes, little is known about the characteristics of protein...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199407000-00002
更新日期:1994-07-01 00:00:00
abstract::Sarcophytol A (SaA), a cembrane-type diterpene isolated from the marine soft coral Sarcophyton glaucum showed anticancer and cancer preventive effects in two different experiments. Growth of transplanted human pancreatic cancer cells (MIA paca-2, 1 x 10(7)) in nude mice (BALB/C 4W female) (Experiment 1) and pancreatic...
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::The Second International Islet Transplantation Symposium was held at UCLA in January, 1993. The symposium, sponsored by the Jerry's Foundation for Diabetes Research was focused on the issues in clinical islet transplantation. The leaders from each of the clinically active programs around the world were invited to disc...
journal_title:Pancreas
pub_type: 杂志文章,评审
doi:10.1097/00006676-199405000-00001
更新日期:1994-05-01 00:00:00
abstract::140 patients with alcoholic acute (recurrent) pancreatitis were enrolled in a prospective long-term study over the last 16 years. Regular control studies regarding progression to advanced chronic pancreatitis were performed. Based on long-term outcome the patients were classified into two groups: group A (n = 109; 77....
journal_title:Pancreas
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::250 syngeneic islets were implanted either beneath the kidney capsule or into the liver of diabetic LEW 1.A rats to investigate the functional response of a limited mass of beta-cells to long-term hyperglycemia. The number of islets, per se, was expected to be insufficient to reverse the hyperglycemia. All animals wer...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199403000-00008
更新日期:1994-03-01 00:00:00
abstract::Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment. Nevertheless, there are few studies concerning its potential toxic effects on islet function. In our study, we have evaluated the effects of DTZ (dissolved i...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199403000-00003
更新日期:1994-03-01 00:00:00
abstract::Examining the actions of L-364,718 on rat pancreatic acini, we found that L-364,718 causes persistent inhibition of cholecystokinin (CCK)-8-stimulated enzyme secretion in acini that were first incubated with L-364,718, washed repeatedly, and then reincubated with CCK-8. This inhibition is maximal after as little as 5 ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199401000-00015
更新日期:1994-01-01 00:00:00
abstract::The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables--including alcohol intake--in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or mo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199401000-00006
更新日期:1994-01-01 00:00:00
abstract::The role of parathyroid hormone (PTH) and calcium on pancreatic exocrine secretion were observed using sham-operated and parathyroidectomized dogs. First, exocrine secretion of the pancreas stimulated with secretin and cholecystokinin octapeptide (CCK-8) was examined in vivo 3 weeks after parathyroidectomy. Secondly, ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199311000-00010
更新日期:1993-11-01 00:00:00
abstract::A comparative study of antibacterial activity of pancreatic juice was conducted on six mammalian species. Pancreatic juice collections were conducted as acute (rabbit, guinea pig, rat) and chronic (pig, sheep, cattle) experiments, in the former before and after stimulation [cholecystokinin (CCK) and secretin] and in t...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00003
更新日期:1993-09-01 00:00:00
abstract::It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of the exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to deter...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00015
更新日期:1993-09-01 00:00:00
abstract::The diagnostic value of bile salt-dependent lipase for pancreatic diseases was tested in sera of 187 patients. Of these patients, 76 suffered from pancreatic carcinoma, 43 from nonmalignant liver diseases (cirrhosis and chronic hepatitis), 18 from acute pancreatitis, and 20 from chronic pancreatitis. The remaining sub...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199309000-00009
更新日期:1993-09-01 00:00:00
abstract::To evaluate the effect of the prostaglandin inhibitor acetylsalicylic acid (ASA) on rat exocrine pancreas secretion, three groups of rats were administered ASA by infusion: Groups 1-3, 50, 100, and 200 mg/kg body wt, respectively; Group 4 received saline. Twenty minutes later these ASA-pretreated groups were given int...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00003
更新日期:1993-07-01 00:00:00
abstract::Pancreatic cancer presenting as acute pancreatitis is relatively uncommon. Pancreatic cancer should be included in the differential diagnosis of "idiopathic" acute pancreatitis, particularly in the elderly. The following case report describes a patient in whom pancreatic cancer presented as acute pancreatitis with pse...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199307000-00016
更新日期:1993-07-01 00:00:00
abstract::Monoclonal antibodies (McAbs) to pancreatic cancer were developed by fusing SP2/0 cells and splenocytes from Balb/c mice immunized with CH-2 cells. The specific binding rates of McAb P1 and P2 were 40.1 and 43.8%, respectively, shown by binding radioreactivity assay in vitro, which were in sharp contrast with those of...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199305000-00002
更新日期:1993-05-01 00:00:00
abstract::In dispersed acini from rat pancreas, verapamil (a phenylalkylamine calcium channel blocker) potentiated amylase secretion stimulated by vasoactive intestinal peptide (VIP), secretin, peptide histidine isoleucine, helodermin, forskolin, and 8-bromocyclic AMP. The action of verapamil on VIP-stimulated amylase secretion...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00012
更新日期:1993-03-01 00:00:00
abstract::Serum expression of the cancer-associated antigens CA 19-9 and CA 50 and their relation to Lewis blood cell status were studied in 26 patients with pancreatic duct carcinoma and 26 patients with pancreatitis. The discriminating capacity between benign and malignant disease was high for both tumor markers. The correspo...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00004
更新日期:1993-03-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) is a 37-amino acid residue polypeptide, originally isolated from the pancreatic amyloid deposits of patients with type II diabetes mellitus. Subsequently, IAPP was found to be colocalised with insulin in beta-cell secretory granules of the normal mammalian pancreas. Recently, IAPP has ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199303000-00019
更新日期:1993-03-01 00:00:00
abstract::A case of papillary cystic tumor (PCT) of the pancreas in a 55-year-old woman is described. She presented with a gradually enlarging and painless abdominal mass for > 26 years. The tumor was encapsulated and measured 16 x 12 x 10 cm. The gross features and conventional light microscopic appearance of this tumor were c...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199301000-00023
更新日期:1993-01-01 00:00:00
abstract::Glucocorticoids are effective in the treatment of certain leukemias and lymphomas, but their effects on the growth of several solid tumors have not been determined. We report here that cortivazol (CVZ), a potent synthetic glucocorticoid, inhibits the growth of a hamster pancreatic adenocarcinoma, H2T, in vivo. CVZ reg...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199301000-00004
更新日期:1993-01-01 00:00:00
abstract::Non-Hodgkin pancreatic lymphoma is a rare disease. Its diagnosis is difficult without histological examination. Ultrasonographic, computed tomodensitometric, and endoscopic retrograde cholangio-pancreatographic findings are not pathognomonic. The better prognosis of these tumors, compared to adenocarcinoma, and their ...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199201000-00017
更新日期:1992-01-01 00:00:00
abstract::Because abnormalities of the autonomic nervous system have been described in several animal models of obesity, and because galanin has been proposed to be a sympathetic neurotransmitter in the endocrine pancreas, we hypothesized that the hyperinsulinemia observed in genetically obese (ob/ob) mice may result either fro...
journal_title:Pancreas
pub_type: 杂志文章
doi:10.1097/00006676-199203000-00016
更新日期:1992-01-01 00:00:00